A viral vector based in vivo model of tauopathy to explore therapeutic strategies against tau pathology

S. M. K. Nazeeruddin

Lausanne, EPFL, 2019.

DOI : 10.5075/epfl-thesis-9532.


Journal Articles

PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease

M. Juneja; A. Azmi; J. Baets; A. Roos; M. Jennings et al.


DOI : 10.1136/jnnp-2017-317562.

Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

N. Mestre-Frances; N. Serratrice; A. Gennetier; G. Devau; S. Cobo et al.


DOI : 10.1172/jci.insight.98202.

Endoplasmic reticulum and mitochondria in diseases of motor and sensory neurons: a broken relationship?

N. Bernard-Marissal; R. Chrast; B. Schneider


DOI : 10.1038/s41419-017-0125-1.

Conference Papers

Cas9/gRNAs Selective Targeting of the Beethoven Tmc-1 Mutant Allele for Treating Progressive Hearing Loss by AAV-Based Delivery

P. Solanes; B. Pan; P. Aebischer; J. R. Holt; B. Schneider

2018-05-01. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) , Chicago, IL , May 16-19, 2018. p. 138-139.

A miRNA-Based Gene Therapy Approach to Target Mutated SOD1 in Key Cell Types in Amyotrophic Lateral Sclerosis {ALS}

V. Vilmont

2018-05-01. 21st Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) , Chicago, IL , May 16-19, 2018. p. 263-263.

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain

A. P. T. Nguyen; G. Daniel; P. Valdés; M. S. Islam; B. L. Schneider et al.

2018-01-01. p. 120-134.

DOI : 10.1093/hmg/ddx389.



AAV based gene therapy for rare diseases

C. C. Rochat

Lausanne, EPFL, 2017.

DOI : 10.5075/epfl-thesis-7888.


Journal Articles

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

P. Machler; M. T. Wyss; M. Elsayed; J. Stobart; R. Gutierrez et al.

Cell Metabolism. 2016.

DOI : 10.1016/j.cmet.2015.10.010.

Amyloid-beta plaque deposition measured using propagation-based X-ray phase contrast CT imaging

A. Astolfo; A. Lathuiliere; V. Laversenne; B. Schneider; M. Stampanoni

Journal Of Synchrotron Radiation. 2016.

DOI : 10.1107/S1600577516004045.

A subcutaneous cellular implant for passive immunization against amyloid-beta reduces brain amyloid and tau pathologies

A. Lathuiliere; V. Laversenne; A. Astolfo; E. Kopetzki; H. Jacobsen et al.

Brain. 2016.

DOI : 10.1093/brain/aww036.

Regulation of Memory Formation by the Transcription Factor XBP1

G. Martinez; R. L. Vidal; P. Mardones; F. G. Serrano; A. O. Ardiles et al.

Cell Reports. 2016.

DOI : 10.1016/j.celrep.2016.01.028.

Conference Papers

Characterization Of Motor And Sensory Neuronal Dysfunction In Both In Vitro And In Vivo Models Of Cmt2A Pathology

N. Bernard-Marissal; C. Rochat; J. J. Medard; B. L. Schneider; R. Chrast

2016. Inflammatory Neuropathy Consortium and GBS 100 Centenary Symposium and Ceilidh , Univ Glasgow, Glasgow, SCOTLAND , JUN 21-24, 2016. p. 239-240.

Use of a Bicistronic Vector to Silence SOD1 in Motoneurons and Astrocytes for the Treatment of Familial Amyotrophic Lateral Sclerosis

J. Bobela-Aebischer; C. Rochat; N. Bernard-Marissal; P. Aebischer; B. L. Schneider

2016. 19th Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT) , Washington, DC , MAY 04-07, 2016. p. S240-S240.


Modulation of AMPK's activity via genetic tools and food-derived compounds as a novel approach to Parkinson's disease treatment

W. J. Bobela

Lausanne, EPFL, 2016.

DOI : 10.5075/epfl-thesis-6978.

The effect of the functional interaction between PGC-1α and Parkin on mitochondrial quality control in Parkinson's disease

L. Zheng

Lausanne, EPFL, 2016.

DOI : 10.5075/epfl-thesis-6868.


Journal Articles

Reply: Is SIGMAR1 a confirmed FTD/MND gene?

N. Bernard-Marissal; J.-J. Medard; H. Azzedine; R. Chrast

Brain. 2015.

DOI : 10.1093/brain/awv174.

Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS

A. Emde; C. Eitan; L.-L. Liou; R. T. Libby; N. Rivkin et al.

Embo Journal. 2015.

SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice

E. Dirren; J. Aebischer; C. Rochat; C. Towne; B. L. Schneider et al.

Annals Of Clinical And Translational Neurology. 2015.

DOI : 10.1002/acn3.162.

Chondroitinase gene therapy improves upper limb function following cervical contusion injury

N. D. James; J. Shea; E. M. Muir; J. Verhaagen; B. L. Schneider et al.

Experimental Neurology. 2015.

DOI : 10.1016/j.expneurol.2015.05.022.

PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein

C. Ciron; L. Zheng; W. Bobela; G. W. Knott; T. C. Leone et al.

Acta Neuropathologica Communications. 2015.

DOI : 10.1186/s40478-015-0200-8.

Tmc gene therapy restores auditory function in deaf mice

C. Askew; C. Rochat; B. Pan; Y. Asai; H. Ahmed et al.

Science Translational Medicine. 2015.

DOI : 10.1126/scitranslmed.aab1996.

Pathway-specific reorganization of projection neurons in somatosensory cortex during learning

J. L. Chen; D. J. Margolis; A. Stankov; L. T. Sumanovski; B. L. Schneider et al.

Nature Neuroscience. 2015.

DOI : 10.1038/nn.4046.

Marinesco-Sjogren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS

A. F. De L'Etang; N. Maharjan; M. C. Brana; C. Ruegsegger; R. Rehmann et al.

Nature Neuroscience. 2015.

DOI : 10.1038/nn.3903.

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

T. Sotelo-Hitschfeld; M. I. Niemeyer; P. Maechler; I. Ruminot; R. Lerchundi et al.

Journal Of Neuroscience. 2015.

DOI : 10.1523/Jneurosci.5036-14.2015.

Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration

N. Bernard-Marissal; J.-J. Medard; H. Azzedine; R. Chrast

Brain. 2015.

DOI : 10.1093/brain/awv008.

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

S. Yang; M. Cacquevel; L. M. Saksida; T. J. Bussey; B. L. Schneider et al.

Experimental neurology. 2015.

DOI : 10.1016/j.expneurol.2014.11.013.


Alpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease

W. Bobela; P. Aebischer; B. L. Schneider

Biomolecules. 2015.

DOI : 10.3390/biom5042675.

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System

A. Lathuiliere; N. Mach; B. L. Schneider

International Journal Of Molecular Sciences. 2015.

DOI : 10.3390/ijms160510578.


Journal Articles

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

J. Dusonchet; H. Li; M. Guillily; M. Liu; K. Stafa et al.

Human Molecular Genetics. 2014.

DOI : 10.1093/hmg/ddu202.

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

P. Valdes; G. Mercado; R. L. Vidal; C. Molina; G. Parsons et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014.

DOI : 10.1073/pnas.1321845111.

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

K. Bartus; N. D. James; A. Didangelos; K. D. Bosch; J. Verhaagen et al.

Journal Of Neuroscience. 2014.

DOI : 10.1523/Jneurosci.4369-13.2014.

FOXO3 determines the accumulation of alpha-synuclein and controls the fate of dopaminergic neurons in the substantia nigra

E. Pino; R. Amamoto; L. Zheng; M. Cacquevel; J.-C. Sarria et al.

Human Molecular Genetics. 2014.

DOI : 10.1093/hmg/ddt530.

Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type-Specific Transgene Expression in the Spinal Cord

E. Dirren; C. L. Towne; V. Setola; D. E. J. Redmond; B. L. Schneider et al.

Human Gene Therapy. 2014.

DOI : 10.1089/hum.2013.021.

Neuronal Matrix Metalloproteinase-9 Is a Determinant of Selective Neurodegeneration

A. Kaplan; K. J. Spiller; C. Towne; K. C. Kanning; G. T. Choe et al.

Neuron. 2014.

DOI : 10.1016/j.neuron.2013.12.009.

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

A. Lathuiliere; B. Bohrmann; E. Kopetzki; C. Schweitzer; H. Jacobsen et al.

Biomaterials. 2014.

DOI : 10.1016/j.biomaterials.2013.10.026.

Cerebrospinal fluid-targeted delivery of neutralizing anti-IFN gamma antibody delays motor decline in an ALS mouse model

B. Otsmane; J. Aebischer; A. Moumen; C. Raoul

Neuroreport. 2014.

DOI : 10.1097/Wnr.0000000000000043.

A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells

A. Lathuilière; S. Cosson; M. Lütolf; B. Schneider; P. Aebischer

Biomaterials. 2014.

DOI : 10.1016/j.biomaterials.2013.09.071.


Journal Articles

Measurement of autophagy flux in the nervous system in vivo

K. Castillo; V. Valenzuela; S. Matus; M. Nassif; M. Onate et al.

Cell Death & Disease. 2013.

DOI : 10.1038/cddis.2013.421.

A spastic paraplegia mouse model reveals REEP1-dependent ER shaping

C. Beetz; N. Koch; M. Khundadze; G. Zimmer; S. Nietzsche et al.

Journal of Clinical Investigation. 2013.

DOI : 10.1172/JCI65665.

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

C. J. Laedermann; M. Cachemaille; G. Kirschmann; M. Pertin; R.-D. Gosselin et al.

Journal Of Clinical Investigation. 2013.

DOI : 10.1172/Jci68996.

Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex

J. L. Chen; S. Carta; J. Soldado-Magraner; B. L. Schneider; F. Helmchen

Nature. 2013.

DOI : 10.1038/nature12236.

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

D. Krakora; P. Mulcrone; M. Meyer; C. Lewis; K. Bernau et al.

Molecular Therapy. 2013.

DOI : 10.1038/mt.2013.108.

Overexpression of parkin in the rat nigrostriatal dopamine system protects against methamphetamine neurotoxicity

B. Liu; R. Traini; B. Killinger; B. L. Schneider; A. Moszczynska

Experimental Neurology. 2013.

DOI : 10.1016/j.expneurol.2013.01.001.

Differential X-ray phase contrast tomography of Alzheimer plaques in mouse models: perspectives for drug development and clinical imaging techniques

B. R. Pinzer; M. Cacquevel; P. Modregger; T. Thuering; M. Stampanoni

Journal Of Instrumentation. 2013.

DOI : 10.1088/1748-0221/8/05/C05005.

Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

K. Loew; P. Aebischer; B. L. Schneider

Human Gene Therapy. 2013.

DOI : 10.1089/hum.2012.174.

Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo

A. Oueslati; B. L. Schneider; P. Aebischer; H. A. Lashuel

Proceedings of the National Academy of Sciences of the United States of America. 2013.

DOI : 10.1073/pnas.1309991110.

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

A. Kunze; S. Lengacher; E. Dirren; P. Aebischer; P. J. Magistretti et al.

Integrative Biology. 2013.

DOI : 10.1039/c3ib40022k.

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

E. Dassie; M. R. Andrews; J.-C. Bensadoun; M. Cacquevel; B. L. Schneider et al.

Neurobiology Of Aging. 2013.

DOI : 10.1016/j.neurobiolaging.2012.11.011.

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

P. Coune; M. Craveiro; M. Gaugler; V. Mlynárik; B. Schneider et al.

NMR in biomedicine. 2013.

DOI : 10.1002/nbm.2817.


AAV-mediated gene therapy against motoneuron diseases

E. A. Dirren

Lausanne, EPFL, 2013.

DOI : 10.5075/epfl-thesis-5821.

A novel encapsulation device for peripheral implantation of antibody-secreting cells

A. Lathuilière

Lausanne, EPFL, 2013.

DOI : 10.5075/epfl-thesis-5796.


Journal Articles

Parkinson's Disease: Gene Therapies

P. G. Coune; B. L. Schneider; P. Aebischer

Cold Spring Harbor Perspectives In Medicine. 2012.

DOI : 10.1101/cshperspect.a009431.

How to build science capacity

B. Fanaroff; P. Aebischer; R. Camacho; I. Serageldin; N. Suetin et al.

Nature. 2012.

DOI : 10.1038/490331a.

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

V. Mlynárik; M. Cacquevel; L. Sun-Reimer; S. Janssens; C. Cudalbu et al.

Journal of Alzheimer's disease : JAD. 2012.

DOI : 10.3233/JAD-2012-112072.

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

B. R. Pinzer; M. Cacquevel; P. Modregger; S. A. McDonald; J. C. Bensadoun et al.

Neuroimage. 2012.

DOI : 10.1016/j.neuroimage.2012.03.029.

Spinal muscular atrophy pathogenic mutations impair the axonogenic properties of axonal-survival of motor neuron

D. Locatelli; P. d'Errico; S. Capra; A. Finardi; F. Colciaghi et al.

Journal Of Neurochemistry. 2012.

DOI : 10.1111/j.1471-4159.2012.07689.x.

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

E. Colla; P. Coune; Y. Liu; O. Pletnikova; J. C. Troncoso et al.

Journal Of Neuroscience. 2012.

DOI : 10.1523/JNEUROSCI.5367-11.2012.

α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer

B. Fauvet; M. K. Mbefo; M.-B. Fares; C. Desobry; S. Michael et al.

The Journal of biological chemistry. 2012.

DOI : 10.1074/jbc.M111.318949.

Mimicking Phosphorylation at Serine 87 Inhibits the Aggregation of Human α-Synuclein and Protects against Its Toxicity in a Rat Model of Parkinson's Disease

A. Oueslati; K. E. Paleologou; B. L. Schneider; P. Aebischer; H. A. Lashuel

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012.

DOI : 10.1523/JNEUROSCI.3784-11.2012.

Philanthropy: The price of charity

P. Aebischer

Nature. 2012.

DOI : 10.1038/481260a.

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

C. Ciron; S. Lengacher; J. Dusonchet; P. Aebischer; B. Schneider

Human Molecular Genetics. 2012.

DOI : 10.1093/hmg/ddr618.


Use of viral vectors to create animal models for Parkinson's disease

K. Loew; P. Aebischer

Neurobiology Of Disease. 2012.

DOI : 10.1016/j.nbd.2011.12.038.


Role of the FoxO3a Transcription Factor in alpha-synuclein Induced Neurodegeneration

E. Pino

Lausanne, EPFL, 2012.

DOI : 10.5075/epfl-thesis-5245.


Journal Articles

Rab1A Over-Expression Prevents Golgi Apparatus Fragmentation and Partially Corrects Motor Deficits in an Alpha-Synuclein Based Rat Model of Parkinson’s Disease

P. G. Coune; J.-C. Bensadoun; P. Aebischer; B. Schneider

Journal of Parkinson's Disease. 2011.

DOI : 10.3233/JPD-2011-11058.

Cell encapsulation technology as a novel strategy for human anti-tumor immunotherapy

F. Schwenter; S. Zarei; P. Luy; V. Padrun; N. Bouche et al.

Cancer Gene Therapy. 2011.

DOI : 10.1038/cgt.2011.22.

Lentiviral vectors express chondroitinase ABC in cortical projections and promote sprouting of injured corticospinal axons

R.-R. Zhao; E. M. Muir; J. N. Alves; H. Rickman; A. Y. Allan et al.

Journal Of Neuroscience Methods. 2011.

DOI : 10.1016/j.jneumeth.2011.08.003.

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

O. Marroquin Belaunzaran; M. I. Cordero; V. Setola; S. Bianchi; C. Galli et al.

Plos One. 2011.

DOI : 10.1371/journal.pone.0018268.

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

J. Dusonchet; O. Kochubey; K. Stafa; S. M. Young; R. Zufferey et al.

Journal of Neuroscience. 2011.

DOI : 10.1523/JNEUROSCI.5092-10.2011.

Conference Papers

Early metabolic changes in the amyotrophic lateral sclerosis SOD1 mouse brain are revealed using 1H MRS rather than CASL and 18FDG PET

H. Lei; E. Dirren; C. Poitry-Yamate; B. Schneider; P. Aebischer et al.

2011. 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine, 2011 , Montréal, Québec, Canada .


Alpha-Synuclein Effects at the ER-to-Golgi Level and Potential Biomarkers in Rat Models of the Early Phase of Parkinson's Disease

P. G. Coune

Lausanne, EPFL, 2011.

DOI : 10.5075/epfl-thesis-5176.


Journal Articles

Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

C. Towne; V. Setola; B. L. Schneider; P. Aebischer

Molecular therapy : the journal of the American Society of Gene Therapy. 2010.

DOI : 10.1038/mt.2010.260.

Neurodegenerative Disorders: Gene Therapy on Clinical Trial

P. Aebischer

Frontiers in Neuroscience. 2010.

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway

K. Langou; A. Moumen; C. Pellegrino; J. Aebischer; I. Medina et al.

Journal of Neurochemistry. 2010.

DOI : 10.1111/j.1471-4159.2010.06806.x.

Collapsin response médiator protein 4a(CRMP 4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron death

L. Duplan; N. Bernard; W. Casseron; K. Dudley; E. Thouvenot et al.

The Journal of Neuroscience. 2010.

DOI : 10.1523/JNEUROSCI.5411-09.2010.

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

A. Mercanzini; S. T. Reddy; D. Velluto; P. Colin; A. Maillard et al.

Journal of Controlled Release. 2010.

DOI : 10.1016/j.jconrel.2010.04.025.

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

C. Towne; B. Schneider; D. Kieran; D. Redmond; P. Aebischer

Gene Therapy. 2010.

DOI : 10.1038/gt.2009.119.

Conference Papers

Alpha-Synuclein Animal Models

M. Gaugler; P. G. Coune; S. Mohana; O. Genc; O. El-Agnaf et al.

2010. 2nd World Parkinson Congress , Glasgow, UK , September 28 - October 1, 2010. p. S606-S606.

Effective Delivery of the Neuroprotectant to the Brain

P. Aebischer; E. Pino; M. Cacquevel; B. Schneider

2010. 2nd World Parkinson Congress , Glasgow, UK , September 28 - October 1, 2010. p. S602-S602.

Nedd4-2 ubiquitin ligase: a contributor to experimental neuropathic pain?

M. Cachemaille; C. Laedermann; M. Pertin; C. Towne; A. T. Beggah et al.

2010. p. 9S-9S.


Long-range connectivity of mouse primary somatosensory barrel cortex

R. Aronoff; F. Matyas; C. Mateo; C. Ciron; B. Schneider et al.

The European journal of neuroscience. 2010.

DOI : 10.1111/j.1460-9568.2010.07264.x.


Motor Deficits upon Alpha-Synuclein Expression in the Nigrostriatal System Are Due to a Loss of Dopaminergic Vesicles and Reduced Dopamine Release at an early Stage of Neurodegeneration

M. Gaugler

Lausanne, EPFL, 2010.

DOI : 10.5075/epfl-thesis-4765.

Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools

J. Dusonchet

Lausanne, EPFL, 2010.

DOI : 10.5075/epfl-thesis-4758.

Adeno-Associated Virus-Mediated Gene Delivery for the Treatment of Amyotrophic Lateral Sclerosis and other Motor Neuron Disorders

C. Towne

Lausanne, EPFL, 2010.

DOI : 10.5075/epfl-thesis-4669.


Use of igf-1 and nt-3 in the treatment of x-linked adrenoleukodystrophy

R. Mastroeni; C. Raoul; P. Aebischer; J.-C. Bensadoun


Patent number(s) :


Journal Articles

Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF

D. J. Redmond; J. Elsworth; R. Roth; C. Leranth; T. Collier et al.

Journal of Comparative Neurology. 2009.

DOI : 10.1002/cne.22028.

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions

Y. Chu; H. Dodiya; P. Aebischer; C. Olanow; J. Kordower

Neurobiology of Disease. 2009.

DOI : 10.1016/j.nbd.2009.05.023.

Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF

M. Emborg; J. Moirano; J. Raschke; V. Bondarenko; R. Zufferey et al.

Neurobiology of Disease. 2009.

DOI : 10.1016/j.nbd.2009.07.022.

Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons

A. Ulusoy; G. Shain; T. Björklund; P. Aebischer; D. Kirik

Molecular Therapy. 2009.

DOI : 10.1038/mt.2009.142.

An in vivo culture system for human embryos using an encapsulation technology: a pilot study

C. Blockeel; P. Mock; G. Verheyen; N. Bouche; P. Le Goff et al.

Human Reproduction. 2009.

DOI : 10.1093/humrep/dep005.

Implication of the JNK pathway in a rat model of Huntington's disease

V. Perrin; N. Dufour; C. Raoul; R. Hassig; E. Brouillet et al.

Experimental Neurology. 2009.

DOI : 10.1016/j.expneurol.2008.10.008.

Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery

C. Towne; M. Pertin; A. Beggah; P. Aebischer; I. Decosterd

Molecular Pain. 2009.

DOI : 10.1186/1744-8069-5-52.

Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model

R. Mastroeni; J.-C. Bensadoun; D. Charvin; P. Aebischer; A. Pujol et al.

Annals of Neurology. 2009.

DOI : 10.1002/ana.21677.

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

J. Dusonchet; J. Bensadoun; B. Schneider; P. Aebischer

Neurobiology of disease. 2009.

DOI : 10.1016/j.nbd.2009.03.013.

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

I. Barde; E. Laurenti; S. Verp; A. C. Groner; C. Towne et al.

Journal of Virology. 2009.

DOI : 10.1128/JVI.00001-09.

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

S. Azeredo da Silveira; B. Schneider; C. Cifuentes-Diaz; D. Sage; T. Abbas-Terki et al.

Human Molecular Genetics. 2009.

DOI : 10.1093/hmg/ddn417.


Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease Through RNAi

C. Towne; P. Aebischer

Methods in molecular biology. 2009.


Immunoisolated cell implants for intracerebral delivery of anti-Aß single chain Fv antibodies in the APP23 Alzheimer's mouse model

O. Marroquin Belaunzaran

Lausanne, EPFL, 2009.

DOI : 10.5075/epfl-thesis-4464.


Journal Articles

Dysregulation of gene expression in primary neuron models of Huntington's disease shows that polyglutamine-related effects on the striatal transcriptome may not be dependent on brain circuitry

H. Runne; E. Régulier; A. Kuhn; D. Zala; O. Gokce et al.

The Journal of neuroscience. 2008.

DOI : 10.1523/JNEUROSCI.3044-08.2008.

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

C. Lo Bianco; J. Shorter; E. Régulier; H. Lashuel; T. Iwatsubo et al.

The Journal of clinical investigation. 2008.

DOI : 10.1172/JCI35781.

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; A. Hayes et al.

Molecular Therapy. 2008.

DOI : 10.1038/mt.2008.197.

Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice

C. Towne; C. Raoul; B. L. Schneider; P. Aebischer

Mol Ther. 2008.

DOI : 10.1038/mt.2008.73.

Conditional gene expression and knockdown using lentivirus vectors encoding shRNA

J. Szulc; P. Aebischer

Methods Mol Biol. 2008.

DOI : 10.1007/978-1-60327-248-3_18.

GDNF-secreting human neural progenitor cells increase tyrosine hydroxylase and VMAT2 expression in MPTP-treated cynomolgus monkeys

M. E. Emborg; A. D. Ebert; J. Moirano; S. Peng; M. Suzuki et al.

Cell Transplant. 2008.

Delta-like 1 participates in the specification of ventral midbrain progenitor derived dopaminergic neurons

M. Bauer; J. Szulc; M. Meyer; C. H. Jensen; T. A. Terki et al.

J Neurochem. 2008.

DOI : 10.1111/j.1471-4159.2007.05037.x.


Viral vectors, animal models and new therapies for Parkinson's disease

B. Schneider; R. Zufferey; P. Aebischer

Parkinsonism Realted Disorders. 2008.

DOI : 10.1016/j.parkreldis.2008.04.024.


Impact of phosphorylation of alpha-synuclein in Parkinson's disease

S. Azeredo da Silveira Lajaunias

Lausanne, EPFL, 2008.

DOI : 10.5075/epfl-thesis-4069.

Book Chapters

Viral vectors: a potent approach to generate genetic models of Parkinson's disease

B. Schneider; M. Gaugler; P. Aebischer

Parkinson's disease: Molecular and therapeutics insights from model systems; New York: Academic Press, 2008. p. 269-281.


Journal Articles

GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS

M. Suzuki; J. McHugh; C. Tork; B. Shelley; S. M. Klein et al.

PLoS ONE. 2007.

DOI : 10.1371/journal.pone.0000689.

Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation

B. L. Schneider; C. R. Seehus; E. E. Capowski; P. Aebischer; S. C. Zhang et al.

Hum Mol Genet. 2007.

DOI : 10.1093/hmg/ddm008.

Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

V. Perrin; E. Régulier; T. Abbas-Terki; R. Hassig; E. Brouillet et al.

Molecular Therapy. 2007.

DOI : 10.1038/

Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates

S. Palfi; E. Brouillet; B. Jarraya; J. Bloch; C. Jan et al.

Mol Ther. 2007.

DOI : 10.1038/

Metabolic correction in oligodendrocytes derived from metachromatic leukodystrophy mouse model by using encapsulated recombinant myoblasts

A. Consiglio; S. Martino; D. Dolcetta; G. Cusella; M. Conese et al.

J Neurol Sci. 2007.

DOI : 10.1016/j.jns.2007.01.010.

Lentiviral vector-mediated genetic modification of human neural progenitor cells for ex vivo gene therapy

E. E. Capowski; B. L. Schneider; A. D. Ebert; C. R. Seehus; J. Szulc et al.

Journal of Neuroscience Methods. 2007.

DOI : 10.1016/j.jneumeth.2007.02.022.

Playing Defense Against Lou Gehrig's Disease

P. Aebischer; A. C. Kato

Scientific American. 2007.

DOI : 10.1038/scientificamerican1107-86.

The KRAB repressor domain can trigger de novo promoter methylation during mouse early embryogenesis

M. Wiznerowicz; J. Jakobsson; J. Szulc; S. Liao; A. Quazzola et al.

Journal of Biological Chemistry. 2007.

DOI : 10.1074/jbc.M705898200.

Conference Papers

From gene to gene therapy and pharmacotherapy, via transgenic animals

P. Aebischer

2007. 11th Congress of the European-Federation-of-Neurological-Societies , Brussels, BELGIUM , Aug 25-28, 2007. p. 2-2.


DJ-1 as a neuroprotective protein in models of Parkinson's disease

K. Piorkowska-Stanco

Lausanne, EPFL, 2007.

DOI : 10.5075/epfl-thesis-3926.


Journal Articles

A versatile tool for conditional gene expression and knockdown

J. Szulc; M. Wiznerowicz; M.-O. Sauvain; D. Trono; P. Aebischer

Nature Methods. 2006.

DOI : 10.1038/nmeth846.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421

R. Pardo; E. Colin; E. Regulier; P. Aebischer; N. Deglon et al.

Journal of Neuroscience. 2006.

DOI : 10.1523/JNEUROSCI.3706-05.2006.

Viral vectors as a tool to model and treat Parkinson's disease

J. Bensadoun; P. Aebischer

Wien Klin Wochenschr. 2006.

DOI : 10.1007/s00508-006-0736-5.

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

M. Arango; S. Holbert; D. Zala; E. Brouillet; J. Pearson et al.

Journal of Neuroscience. 2006.

DOI : 10.1523/JNEUROSCI.5409-05.2006.

Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease

A. Sajadi; J. Bensadoun; B. Schneider; C. Lo Bianco; P. Aebischer

Neurobiol Dis. 2006.

DOI : 10.1016/j.nbd.2005.10.006.

Lentivirus-mediated expression of glutathione peroxidase: neuroprotection in murine models of Parkinson's disease

J. L. Ridet; J. Bensadoun; N. Deglon; P. Aebischer; A. D. Zurn

Neurobiol Dis. 2006.

DOI : 10.1016/j.nbd.2005.06.003.

Inducing tolerance to a soluble foreign antigen by encapsulated cell transplants

W. E. Blanco-Bose; B. L. Schneider; P. Aebischer

Mol Ther. 2006.

DOI : 10.1016/j.ymthe.2005.08.010.

Role of dopamine in Huntington's disease

J. Caboche; D. Charvin

Med Sci (Paris). 2006.

Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates

S. Behrstock; A. Ebert; J. McHugh; S. Vosberg; J. Moore et al.

Gene Ther. 2006.

DOI : 10.1038/

Chronic activation in presymptomatic amyotrophic lateral sclerosis (ALS) mice of a feedback loop involving Fas, Daxx, and FasL

C. Raoul; E. Buhler; C. Sadeghi; A. Jacquier; P. Aebischer et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2006.

DOI : 10.1073/pnas.0508774103.


Viral-based modelling and correction of neurodegenerative diseases by RNA interference

C. Raoul; S. D. Barker; P. Aebischer

Gene therapy. 2006.

Book Chapters

The potential of gene therapy for motor neuron diseases

C. Raoul; P. Aebischer

Amyotrophic Lateral Sclerosis; New York, NY: Taylor&Francis, 2006. p. 505-524.


Journal Articles

GDNF delivery using human neural progenitor cells in a rat model of ALS

S. M. Klein; S. Behrstock; J. McHugh; K. Hoffmann; K. Wallace et al.

Hum Gene Ther. 2005.

DOI : 10.1089/hum.2005.16.509.

Akt is altered in an animal model of Huntington's disease and in patients

E. Colin; E. Regulier; V. Perrin; A. Durr; A. Brice et al.

European Journal of Neuroscience. 2005.

DOI : 10.1111/j.1460-9568.2005.03985.x.

Increased fiber outgrowth from xeno-transplanted human embryonic dopaminergic neurons with co-implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor

Y. H. Ahn; J. Bensadoun; P. Aebischer; A. D. Zurn; A. Seiger et al.

Brain Res Bull. 2005.

DOI : 10.1016/j.brainresbull.2005.04.009.

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment

D. Zala; A. Benchoua; E. Brouillet; V. Perrin; M. C. Gaillard et al.

Neurobiol Dis. 2005.

DOI : 10.1016/j.nbd.2005.05.017.

Long-term glial cell line-derived neurotrophic factor overexpression in the intact nigrostriatal system in rats leads to a decrease of dopamine and increase of tetrahydrobiopterin production

A. Sajadi; M. Bauer; B. Thony; P. Aebischer

J Neurochem. 2005.

DOI : 10.1111/j.1471-4159.2005.03139.x.

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS

C. Raoul; T. Abbas-Terki; J. Bensadoun; S. Guillot; G. Haase et al.

Nat Med. 2005.

DOI : 10.1038/nm1207.

Expression of a dominant negative form of Daxx in vivo rescues motoneurons from Fas (CD95)-induced cell death

C. Raoul; C. Barthelemy; A. Couzinet; D. Hancock; B. Pettmann et al.

J Neurobiol. 2005.

DOI : 10.1002/neu.20086.

Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo

M. N. M. Gaugler; J. Tracy; K. Kuhnle; A. Crameri; R. M. Nitsch et al.

FEBS Lett. 2005.

DOI : 10.1016/j.febslet.2005.01.002.

Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation

D. Charvin; P. Vanhoutte; C. Pagès; E. Borrelli; E. Borelli et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2005.

DOI : 10.1073/pnas.0502698102.


Transgenic SOD1 mice as a model for developing amyotrophic lateral sclerosis therapies

S. Guillot

Lausanne, EPFL, 2005.

DOI : 10.5075/epfl-thesis-3331.

Dopaminergic fiber protection and regeneration by Wlds protein and GDNF in rodent models of Parkinson disease

A. Etemad-Sajadi

Lausanne, EPFL, 2005.

DOI : 10.5075/epfl-thesis-3265.

Use of lentiviral vectors for modelling and treating Parkinson's disease

C. Lo Bianco

Lausanne, EPFL, 2005.

DOI : 10.5075/epfl-thesis-3167.

Huntington's disease modeling and treatment

D. Zala

Lausanne, EPFL, 2005.

DOI : 10.5075/epfl-thesis-3137.


Journal Articles

ALS, IGF-1 and gene therapy: 'it's never too late to mend'

C. Raoul; P. Aebischer

Gene Ther. 2004.

DOI : 10.1038/

Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons

H. Kishima; T. Poyot; J. Bloch; J. Dauguet; F. Conde et al.

Neurobiol Dis. 2004.

DOI : 10.1016/j.nbd.2004.03.012.

Wlds-mediated protection of dopaminergic fibers in an animal model of Parkinson disease

A. Sajadi; B. L. Schneider; P. Aebischer

Curr Biol. 2004.

DOI : 10.1016/S0960-9822(04)00050-8.

Survival of encapsulated human primary fibroblasts and erythropoietin expression under xenogeneic conditions

F. Schwenter; B. L. Schneider; W. F. Pralong; N. Deglon; P. Aebischer

Hum Gene Ther. 2004.

DOI : 10.1089/1043034041361172.

Salivary glands and gene therapy: the mouth waters

R. Zufferey; P. Aebischer

Gene Ther. 2004.

DOI : 10.1038/

Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study

J. Bloch; A. C. Bachoud-Levi; N. Deglon; J. P. Lefaucheur; L. Winkel et al.

Hum Gene Ther. 2004.

DOI : 10.1089/hum.2004.15.968.

Long-term lentiviral-mediated expression of ciliary neurotrophic factor in the striatum of Huntington's disease transgenic mice

D. Zala; J. Bensadoun; L. Pereira de Almeida; B. R. Leavitt; C. A. Gutekunst et al.

Exp Neurol. 2004.

DOI : 10.1016/j.expneurol.2003.09.002.

Local GDNF expression mediated by lentiviral vector protects facial nerve motoneurons but not spinal motoneurons in SOD1(G93A) transgenic mice

S. Guillot; M. Azzouz; N. Deglon; A. Zurn; P. Aebischer

Neurobiol Dis. 2004.

DOI : 10.1016/j.nbd.2004.01.017.

Lentiviral-mediated gene transfer to model triplet repeat disorders

E. Regulier; D. Zala; P. Aebischer; N. Deglon

Methods Mol Biol. 2004.

DOI : 10.1385/1-59259-804-8:199.

Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease

C. Lo Bianco; B. L. Schneider; M. Bauer; A. Sajadi; A. Brice et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2004.

DOI : 10.1073/pnas.0405313101.

Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease

C. Lo Bianco; N. Deglon; W. Pralong; P. Aebischer

Neurobiol Dis. 2004.

DOI : 10.1016/j.nbd.2004.06.008.

In vivo calcium deposition on polyvinyl alcohol matrix used in hollow fiber cell macroencapsulation devices

F. Schwenter; N. Bouche; W. F. Pralong; P. Aebischer

Biomaterials. 2004.

DOI : 10.1016/j.biomaterials.2003.10.030.

Using human neural stem cells to model neurological disease

R. J. Jakel; B. L. Schneider; C. N. Svendsen

Nat Rev Genet. 2004.

DOI : 10.1038/nrg1268.

Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture

M. Garcia; D. Charvin; J. Caboche

Neuroscience. 2004.

DOI : 10.1016/j.neuroscience.2004.05.054.

Free operant and discrete trial performance of mice in the nine-hole box apparatus: validation using amphetamine and scopolamine

J. Bensadoun; S. P. Brooks; S. B. Dunnett

Psychopharmacology (Berl). 2004.

DOI : 10.1007/s00213-003-1751-0.


Journal Articles

Prevention of the initial host immuno-inflammatory response determines the long-term survival of encapsulated myoblasts genetically engineered for erythropoietin delivery

B. L. Schneider; F. Schwenter; W. F. Pralong; P. Aebischer

Mol Ther. 2003.

DOI : 10.1016/S1525-0016(03)00055-8.

Presence of Gal-alpha1,3Gal epitope on xenogeneic lines: implications for cellular gene therapy based on the encapsulation technology

N. Deglon; V. Aubert; F. Spertini; L. Winkel; P. Aebischer

Xenotransplantation. 2003.

DOI : 10.1034/j.1399-3089.2003.00110.x.

Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy

F. Schwenter; N. Deglon; P. Aebischer

J Gene Med. 2003.

DOI : 10.1002/jgm.338.

Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum

E. Regulier; Y. Trottier; V. Perrin; P. Aebischer; N. Deglon

Hum Mol Genet. 2003.

DOI : 10.1093/hmg/ddg305.

Comparative study of GDNF delivery systems for the CNS: polymer rods, encapsulated cells, and lentiviral vectors

J. Bensadoun; L. Pereira de Almeida; E. G. Fine; J. L. Tseng; N. Deglon et al.

J Control Release. 2003.

DOI : 10.1016/S0168-3659(02)00353-X.

Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo

G. Ugolini; C. Raoul; A. Ferri; C. Haenggeli; Y. Yamamoto et al.

Journal of Neuroscience. 2003.

Lentivirus-mediated transduction of connexin cDNAs shows level- and isoform-specific alterations in insulin secretion of primary pancreatic beta-cells

D. Caton; A. Calabrese; C. Mas; V. Serre-Beinier; A. Charollais et al.

Journal of Cell Science. 2003.

DOI : 10.1242/jcs.00442.

Insulin-like growth factor-II bound to vitronectin enhances MCF-7 breast cancer cell migration

A. Noble; C. Towne; L. Chopin; D. Leavesley; Z. Upton

Endocrinology. 2003.

DOI : 10.1210/en.2002-221138.

Structural and functional evidence for the interaction of insulin-like growth factors (IGFs) and IGF binding proteins with vitronectin

J. A. Kricker; C. L. Towne; S. M. Firth; A. C. Herington; Z. Upton

Endocrinology. 2003.

DOI : 10.1210/en.2002-221086.

Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus

D. Charvin; C. Cifuentes-Diaz; N. Fonknechten; V. Joshi; J. Hazan et al.

Hum Mol Genet. 2003.

DOI : 10.1093/hmg/ddg004.

Activity analysis of housekeeping promoters using self-inactivating lentiviral vector delivery into the mouse retina

C. Kostic; F. Chiodini; P. Salmon; M. Wiznerowicz; N. Deglon et al.

Gene Ther. 2003.

DOI : 10.1038/


Cellular implants: pioneers in xenotransplantation?

B. L. Schneider; P. Aebischer

Xenotransplantation. 2003.

DOI : 10.1034/j.1399-3089.2003.02086.x.


Enhancement of peripheral nerve regeneration by interactive biomaterials

E. G. Fine

Lausanne, EPFL, 2003.

DOI : 10.5075/epfl-thesis-2423.

Book Chapters

Cell therapy using encapsulated cells producing endostatin

R. Bjerkvig; T. A. Read; P. Vajkoczy; P. Aebischer; W. Pralong et al.

Local Therapies for Glioma; New York, NY: Springer, 2003. p. 137-141.


Journal Articles

Allogeneic beta-islet cells correct diabetes and resist immune rejection

M. Pericin; A. Althage; S. Freigang; H. Hengartner; E. Rolland et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002.

DOI : 10.1073/pnas.122241299.

Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration

S. Palfi; L. Leventhal; Y. Chu; S. Y. Ma; M. Emborg et al.

Journal of Neuroscience. 2002.

Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons

T. Ostenfeld; Y. T. Tai; P. Martin; N. Deglon; P. Aebischer et al.

Journal of Neuroscience Res. 2002.

DOI : 10.1002/jnr.10396.

Seizure suppression by adenosine-releasing cells is independent of seizure frequency

D. Boison; A. Huber; V. Padrun; N. Deglon; P. Aebischer et al.

Epilepsia. 2002.

DOI : 10.1046/j.1528-1157.2002.33001.x.

Simultaneous GDNF and BDNF application leads to increased motoneuron survival and improved functional outcome in an experimental model for obstetric brachial plexus lesions

O. C. Aszmann; K. J. Korak; N. Kropf; E. Fine; P. Aebischer et al.

Plast Reconstr Surg. 2002.

DOI : 10.1097/01.PRS.0000020990.82332.43.

Long-term doxycycline-regulated secretion of erythropoietin by encapsulated myoblasts

B. Sommer; C. Rinsch; E. Payen; B. Dalle; B. Schneider et al.

Mol Ther. 2002.

DOI : 10.1006/mthe.2002.0646.

Lentiviral-mediated RNA interference

T. Abbas-Terki; W. Blanco-Bose; N. Deglon; W. Pralong; P. Aebischer

Hum Gene Ther. 2002.

DOI : 10.1089/104303402320987888.

Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length

L. P. de Almeida; C. A. Ross; D. Zala; P. Aebischer; N. Deglon

Journal of Neuroscience. 2002.

Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat

F. M. Barras; P. Pasche; N. Bouche; P. Aebischer; A. D. Zurn

Journal of Neuroscience Res. 2002.

DOI : 10.1002/jnr.10434.

GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap

E. G. Fine; I. Decosterd; M. Papaloizos; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 2002.

DOI : 10.1046/j.1460-9568.2002.01892.x.

Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease

E. Regulier; L. Pereira de Almeida; B. Sommer; P. Aebischer; N. Deglon

Hum Gene Ther. 2002.

DOI : 10.1089/10430340260355383.

Delivery of erythropoietin by encapsulated myoblasts in a genetic model of severe anemia

C. Rinsch; P. Dupraz; B. L. Schneider; N. Deglon; P. H. Maxwell et al.

Kidney Int. 2002.

DOI : 10.1111/j.1523-1755.2002.kid574.x.

alpha -Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease

C. Lo Bianco; J. L. Ridet; B. L. Schneider; N. Deglon; P. Aebischer

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2002.

DOI : 10.1073/pnas.152339799.

Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations

C. Raoul; A. G. Estévez; H. Nishimune; D. W. Cleveland; O. deLapeyrière et al.

Neuron. 2002.

DOI : 10.1016/S0896-6273(02)00905-4.


Lentiviruses as vectors for CNS diseases

N. Deglon; P. Aebischer

Current topics in microbiology and immunology. 2002.

Book Chapters

Encapsulation as a strategy for cell xenotransplantation

B. Schneider; P. Aebischer

Future strategies for tissue and organ replacement; London: Imperial College Press, 2002. p. 291-322.


Journal Articles

In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice

A. Consiglio; A. Quattrini; S. Martino; J. Bensadoun; D. Dolcetta et al.

Nature medicine. 2001.

DOI : 10.1038/85454.

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

A. Huber; V. Padrun; N. Deglon; P. Aebischer; H. Mohler et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 2001.

DOI : 10.1073/pnas.131102898.

Viral vector-mediated gene therapy for Parkinson's disease

M. Emborg; N. Deglon; L. Leventhal; P. Aebischer; J. Kordower

Clin Neurosci Res. 2001.

DOI : 10.1016/S1566-2772(01)00027-5.

A self-immunomodulating myoblast cell line for erythropoietin delivery

B. L. Schneider; G. Peduto; P. Aebischer

Gene Ther. 2001.

DOI : 10.1038/

Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome

J. Bensadoun; L. P. de Almeida; M. Dreano; P. Aebischer; N. Deglon

European Journal of Neuroscience. 2001.

DOI : 10.1046/j.0953-816x.2001.01802.x.

Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease

L. P. de Almeida; D. Zala; P. Aebischer; N. Deglon

Neurobiol Dis. 2001.

DOI : 10.1006/nbdi.2001.0388.

Nerve growth factor- and neurotrophin-3-releasing guidance channels promote regeneration of the transected rat dorsal root

J. Bloch; E. G. Fine; N. Bouche; A. D. Zurn; P. Aebischer

Exp Neurol. 2001.

DOI : 10.1006/exnr.2001.7778.

Isolation of multipotent neural precursors residing in the cortex of the adult human brain

Y. Arsenijevic; J. G. Villemure; J. F. Brunet; J. J. Bloch; N. Deglon et al.

Exp Neurol. 2001.

DOI : 10.1006/exnr.2001.7691.

Insulin-like growth factor-I is necessary for neural stem cell proliferation and demonstrates distinct actions of epidermal growth factor and fibroblast growth factor-2

Y. Arsenijevic; S. Weiss; B. Schneider; P. Aebischer

Journal of Neuroscience. 2001.

DOI : 10.1523/JNEUROSCI.21-18-07194.2001.

Inducing host acceptance to encapsulated xenogeneic myoblasts

C. Rinsch; G. Peduto; B. L. Schneider; P. Aebischer

Transplantation. 2001.

DOI : 10.1097/00007890-200102150-00002.

Delivery of FGF-2 but not VEGF by encapsulated genetically engineered myoblasts improves survival and vascularization in a model of acute skin flap ischemia

C. Rinsch; P. Quinodoz; B. Pittet; N. Alizadeh; D. Baetens et al.

Gene Ther. 2001.

DOI : 10.1038/

Organ distribution of gene expression after intravenous infusion of targeted and untargeted lentiviral vectors

K. W. Peng; L. Pham; H. Ye; R. Zufferey; D. Trono et al.

Gene Ther. 2001.

DOI : 10.1038/


Recombinant proteins for neurodegenerative diseases: the delivery issue

P. Aebischer; J. Ridet

Trends in neurosciences. 2001.

DOI : 10.1016/S0166-2236(00)01899-3.

Sustained delivery of GDNF: towards a treatment for Parkinson's disease

A. D. Zurn; H. R. Widmer; P. Aebischer

Brain Res Brain Res Rev. 2001.

DOI : 10.1016/S0165-0173(01)00098-4.

Book Chapters

Polymer-encapsulated cells as a tool for drug delivery and neural transplantation in Parkinson's disease

J. Bensadoun; H. Widmer

Surgery for Parkinson's disease and movement disorders; Philadelphia: Lippincott Williams & Wilkins, 2001. p. 245-251.

Encapsulated cell implants as a novel treatment for Parkinson’s disease

J. Tseng; P. Aebischer

Parkinson's disease: Methods and Protocols; Totowa, NJ: Humana Press, 2001. p. 279-288.


Journal Articles

Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease

V. Mittoux; J. M. Joseph; F. Conde; S. Palfi; C. Dautry et al.

Hum Gene Ther. 2000.

DOI : 10.1089/10430340050015220.

Efficient gene transfer and expression of biologically active glial cell line-derived neurotrophic factor in rat motoneurons transduced wit lentiviral vectors

C. Cisterni; C. E. Henderson; P. Aebischer; B. Pettmann; N. Deglon

J Neurochem. 2000.

DOI : 10.1046/j.1471-4159.2000.0741820.x.

Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF

A. C. Bachoud-Levi; N. Deglon; J. P. Nguyen; J. Bloch; C. Bourdet et al.

Hum Gene Ther. 2000.

DOI : 10.1089/10430340050111377.

Long-term host unresponsiveness to encapsulated xenogeneic myoblasts after transient immunosuppression

G. Peduto; C. Rinsch; B. L. Schneider; E. Rolland; P. Aebischer

Transplantation. 2000.

Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF

J. Bensadoun; N. Deglon; J. L. Tseng; J. L. Ridet; A. D. Zurn et al.

Exp Neurol. 2000.

DOI : 10.1006/exnr.2000.7409.

Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2

M. Azzouz; A. Hottinger; J. C. Paterna; A. D. Zurn; P. Aebischer et al.

Hum Mol Genet. 2000.

DOI : 10.1093/hmg/9.5.803.

Evaluation of an intrathecal immune response in amyotrophic lateral sclerosis patients implanted with encapsulated genetically engineered xenogeneic cells

A. D. Zurn; H. Henry; M. Schluep; V. Aubert; L. Winkel et al.

Cell Transplant. 2000.

Encapsulated neural transplants

J. L. Tseng; P. Aebischer

Prog Brain Res. 2000.

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus

A. F. Hottinger; M. Azzouz; N. Deglon; P. Aebischer; A. D. Zurn

Journal of Neuroscience. 2000.

Active killing of neurons during development and following stress: a role for p75(NTR) and Fas?

C. Raoul; B. Pettmann; C. E. Henderson

Curr Opin Neurobiol. 2000.

DOI : 10.1016/S0959-4388(99)00055-0.

Lentivirus-mediated gene transfer of gp91phox corrects chronic granulomatous disease (CGD) phenotype in human X-CGD cells

S. O. Saulnier; D. Steinhoff; M. C. Dinauer; R. Zufferey; D. Trono et al.

J Gene Med. 2000.

DOI : 10.1002/1521-2254(200009/10)2:5<317::AID-JGM127>3.0.CO;2-P.

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

J. C. Schense; J. Bloch; P. Aebischer; J. A. Hubbell

Nature biotechnology. 2000.

DOI : 10.1038/74473.

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

I. Hamaguchi; N. B. Woods; I. Panagopoulos; E. Andersson; H. Mikkola et al.

Journal of Virology. 2000.

DOI : 10.1128/JVI.74.22.10778-10784.2000.

Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease

N. Déglon; J. L. Tseng; J. Bensadoun; A. D. Zurn; Y. Arsenijevic et al.

Hum Gene Ther. 2000.

DOI : 10.1089/10430340050016256.

A stable system for the high-titer production of multiply attenuated lentiviral vectors

N. Klages; R. Zufferey; D. Trono

Mol Ther. 2000.

DOI : 10.1006/mthe.2000.0103.

Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

J. H. Kordower; M. E. Emborg; J. Bloch; S. Y. Ma; Y. Chu et al.

Science. 2000.

DOI : 10.1126/science.290.5492.767.

Lentiviral gene transfer into primary and secondary NOD/SCID repopulating cells

N. B. Woods; C. Fahlman; H. Mikkola; I. Hamaguchi; K. Olsson et al.

Blood. 2000.


Gene transfer techniques for the delivery of GDNF in Parkinson's disease

J. L. Ridet; N. Deglon; P. Aebischer

Novartis Foundation symposium. 2000.


Journal Articles

Treatment of diseases of the central nervous system using encapsulated cells

A. F. Hottinger; P. Aebischer

Adv Tech Stand Neurosurg. 1999.

Sniff nasal pressure: a sensitive respiratory test to assess progression of amyotrophic lateral sclerosis

J. W. Fitting; R. Paillex; L. Hirt; P. Aebischer; M. Schluep

Annals of Neurology. 1999.

DOI : 10.1002/1531-8249(199912)46:6<887::AID-ANA11>3.0.CO;2-L.

Highlights of the cell transplantation meeting at Montreux, March 1999

C. Rinsch; B. L. Schneider; P. Aebischer

Cell Transplant. 1999.

Programmed cell death of embryonic motoneurons triggered through the Fas death receptor

C. Raoul; C. E. Henderson; B. Pettmann

Journal of Cell Biology. 1999.

DOI : 10.1083/jcb.147.5.1049.

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors

R. Zufferey; J. E. Donello; D. Trono; T. J. Hope

Journal of Virology. 1999.

Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion

P. Dupraz; C. Rinsch; W. F. Pralong; E. Rolland; R. Zufferey et al.

Gene Ther. 1999.

DOI : 10.1038/

Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector

J. J. Han; A. N. Mhatre; M. Wareing; R. Pettis; W. Q. Gao et al.

Hum Gene Ther. 1999.

DOI : 10.1089/10430349950017545.


Journal Articles

Three-dimensional extracellular matrix engineering in the nervous system

M. Borkenhagen; J. F. Clemence; H. Sigrist; P. Aebischer

J Biomed Mater Res. 1998.

DOI : 10.1002/(SICI)1097-4636(19980603)40:3<392::AID-JBM8>3.0.CO;2-C.

Neurturin protects dopaminergic neurons following medial forebrain bundle axotomy

J. L. Tseng; S. L. Bruhn; A. D. Zurn; P. Aebischer

Neuroreport. 1998.

DOI : 10.1097/00001756-199806010-00027.

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

I. Decosterd; E. Buchser; N. Gilliard; J. Saydoff; A. D. Zurn et al.

Pain. 1998.

DOI : 10.1016/S0304-3959(98)00044-X.

In vivo performance of a new biodegradable polyester urethane system used as a nerve guidance channel

M. Borkenhagen; R. C. Stoll; P. Neuenschwander; U. W. Suter; P. Aebischer

Biomaterials. 1998.

DOI : 10.1016/S0142-9612(98)00122-7.

A gene therapy approach for the treatment of amyotrophic lateral sclerosis and Parkinson's disease

A. D. Zurn; J. L. Tseng; N. Deglon; J. M. Joseph; P. Aebischer

Adv Pharmacol. 1998.

Continuous delivery of human and mouse erythropoietin in mice by genetically engineered polymer encapsulated myoblasts

E. Regulier; B. L. Schneider; N. Deglon; Y. Beuzard; P. Aebischer

Gene Ther. 1998.

Attenuation of 6-OHDA-induced neurotoxicity in glutathione peroxidase transgenic mice

J. Bensadoun; O. Mirochnitchenko; M. Inouye; P. Aebischer; A. D. Zurn

European Journal of Neuroscience. 1998.

DOI : 10.1046/j.1460-9568.1998.00345.x.

Application of Teflon-AF thin films for bio-patterning of neural cell adhesion

S. A. Makohliso; L. Giovangrandi; D. Leonard; H. J. Mathieu; M. Ilegems et al.

Biosens Bioelectron. 1998.

DOI : 10.1016/S0956-5663(98)00036-0.

A third-generation lentivirus vector with a conditional packaging system

T. Dull; R. Zufferey; M. Kelly; R. J. Mandel; M. Nguyen et al.

Journal of Virology. 1998.

Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery

R. Zufferey; T. Dull; R. J. Mandel; A. Bukovsky; D. Quiroz et al.

Journal of Virology. 1998.


A surface engineering approach towards the development of cell-based biochip sensors

S. Makohliso

Lausanne, EPFL, 1998.

DOI : 10.5075/epfl-thesis-1848.


Journal Articles

Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization

N. A. Pochon; A. Menoud; J. L. Tseng; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997.

DOI : 10.1111/j.1460-9568.1997.tb01623.x.

A gene therapy approach to regulated delivery of erythropoietin as a function of oxygen tension

C. Rinsch; E. Regulier; N. Deglon; B. Dalle; Y. Beuzard et al.

Hum Gene Ther. 1997.

GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine

J. L. Tseng; E. E. Baetge; A. D. Zurn; P. Aebischer

Journal of Neuroscience. 1997.

The copper chelator d-penicillamine delays onset of disease and extends survival in a transgenic mouse model of familial amyotrophic lateral sclerosis

A. F. Hottinger; E. G. Fine; M. E. Gurney; A. D. Zurn; P. Aebischer

European Journal of Neuroscience. 1997.

DOI : 10.1111/j.1460-9568.1997.tb01511.x.

A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro

G. Reiss; S. te Heesen; R. Gilmore; R. Zufferey; M. Aebi

EMBO Journal. 1997.

DOI : 10.1093/emboj/16.6.1164.

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

R. Zufferey; D. Nagy; R. J. Mandel; L. Naldini; D. Trono

Nat Biotechnol. 1997.

DOI : 10.1038/nbt0997-871.


Tissue engineering approaches for peripheral nerve regeneration

M. Borkenhagen

Lausanne, EPFL, 1997.

DOI : 10.5075/epfl-thesis-1688.


Journal Articles

Treatment of Parkinson's disease. Symptomatic cell therapies: cells as biological minipumps

A. D. Zurn; J. Tseng; P. Aebischer

Eur Neurol. 1996.

Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF

S. A. Tan; N. Deglon; A. D. Zurn; E. E. Baetge; B. Bamber et al.

Cell Transplant. 1996.

The problems of delivering neuroactive molecules to the CNS

S. A. Tan; P. Aebischer

Ciba Found Symp. 1996.

Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients

P. Aebischer; M. Schluep; N. Deglon; J. M. Joseph; L. Hirt et al.

Nat Med. 1996.

DOI : 10.1038/nm0696-696.

Immunoisolated xenogenic chromaffin cell therapy for chronic pain. Initial clinical experience

E. Buchser; M. Goddard; B. Heyd; J. M. Joseph; J. Favre et al.

Anesthesiology. 1996.

DOI : 10.1097/00000542-199611000-00007.

Gene therapy for amyotrophic lateral sclerosis (ALS) using a polymer encapsulated xenogenic cell line engineered to secrete hCNTF

P. Aebischer; N. A. Pochon; B. Heyd; N. Deglon; J. M. Joseph et al.

Hum Gene Ther. 1996.

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

A. D. Zurn; L. Winkel; A. Menoud; K. Djabali; P. Aebischer

Journal of Neuroscience Res. 1996.

DOI : 10.1002/(SICI)1097-4547(19960415)44:2<133::AID-JNR5>3.0.CO;2-E.

Central nervous system delivery of recombinant ciliary neurotrophic factor by polymer encapsulated differentiated C2C12 myoblasts

N. Deglon; B. Heyd; S. A. Tan; J. M. Joseph; A. D. Zurn et al.

Hum Gene Ther. 1996.


Journal Articles

Treatment of amyotrophic lateral sclerosis using a gene therapy approach

P. Aebischer; A. C. Kato

Eur Neurol. 1995.

Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; T. G. Vargo; J. A. Gardella et al.

J Biomed Mater Res. 1995.

DOI : 10.1002/jbm.820290614.

Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro

R. Bellamkonda; J. P. Ranieri; P. Aebischer

Journal of Neuroscience Res. 1995.

DOI : 10.1002/jnr.490410409.

Hydrogel-based three-dimensional matrix for neural cells

R. Bellamkonda; J. P. Ranieri; N. Bouche; P. Aebischer

J Biomed Mater Res. 1995.

DOI : 10.1002/jbm.820290514.

The A985G mutation in the medium-chain acyl-CoA dehydrogenase gene: high prevalence in the Swiss population resident in Geneva

B. Conne; R. Zufferey; D. Belin

J Inherit Metab Dis. 1995.

DOI : 10.1007/BF02436002.

STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo

R. Zufferey; R. Knauer; P. Burda; I. Stagljar; S. te Heesen et al.

EMBO Journal. 1995.


Journal Articles

Transplantation in humans of encapsulated xenogeneic cells without immunosuppression. A preliminary report

P. Aebischer; E. Buchser; J. M. Joseph; J. Favre; N. de Tribolet et al.

Transplantation. 1994.

Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates

J. P. Ranieri; R. Bellamkonda; E. J. Bekos; J. A. Gardella; H. J. Mathieu et al.

Int J Dev Neurosci. 1994.

Glial cell line-derived neurotrophic factor (GDNF), a new neurotrophic factor for motoneurones

A. D. Zurn; E. E. Baetge; J. P. Hammang; S. A. Tan; P. Aebischer

Neuroreport. 1994.

DOI : 10.1097/00001756-199412300-00030.

Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes

P. L. Herrera; J. Huarte; R. Zufferey; A. Nichols; B. Mermillod et al.

Proceedings Of The National Academy Of Sciences Of The United States Of America. 1994.

DOI : 10.1073/pnas.91.26.12999.