► Development and characterization of genetic virus-based models through direct injection in the nigro-striatal system

► Target genes: alpha-synuclein, LRRK2

► Involvement of age-related genes in PD pathology

► Evaluation of therapeutic genes and compounds in PD models

► Investigation of adeno-associated vectors (AAV) in the nigro-striatal system: role of the promoter, the serotype and the route of administration on the transduction pattern