Research

Research Interests

The main focus of our laboratory is to develop gene therapy approaches for the treatment of neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease and motoneuron diseases. Our laboratory is also implicated in the development of new animal models based on virus-mediated overexpression or silencing of genes involved in neurodegenerative diseases. For both gene therapy and development of models, viral vectors such as lentivirus and adeno-associated virus are produced and used in our laboratory. For therapeutic purposes, the technique of genetically engineered encapsulated cells allowing the localized secretion of various proteins as well as drug-testing are also widely implemented. The functional effects are characterized through the use of a wide variety of techniques including behavioural assessment, in vivo imaging techniques, morphological analysis and biochemical measurements.